Yes, I feel that way a lot. I think it is mostly when I don't think I am in God's will or when I have neglected spending quality time with Him and/or His church. I think [Psalm 42:1-2] captures that feeling for me pretty well..."As the deer pants for streams of water,
so my soul pants for you, O God. My soul thirsts for God, for the living God.
When can I go and meet with God?" (NIV) Jesus also speaks of giving us "Living Water" to satisfy our spiritual thirst. [John 4:10-14]and [Revelation 22:17]